Cypionate

(Testosterone Cypionate)

Testosterone is the hormone that makes men, well, men! In this Profile, we´ll take a look at testosterone cypionate, and examine the pros and cons of its use to improve performance in athletics and bodybuilding.

Testosterone is the hormone responsible for many different physical and mental characteristics in males. It promotes sex drive, fat loss, helps with gaining and maintaining lean muscle mass and bone density and may even protect against heart disease.(1) All other steroids are actually the testosterone molecule that has been altered to change the properties of the hormone. This would make testosterone the "father" of all other steroids employed by athletes today. In fact, testosterone is the standard for the anabolic/androgenic ratio we use, it´s a "perfect" 100 score, against which we measure all other steroids.

As I previously stated, testosterone is a highly anabolic and androgenic hormone, it has an anabolic (muscle building) rating of 100, making it a good drug to use if one is in pursuit of more size and strength. And if you aren´t in pursuit of more size and strength, then why would you be reading this, right? Well, let´s get on with it and look at exactly what makes testosterone a good mass builder. Firstly, testosterone promotes nitrogen retention in the muscle (2) the more nitrogen the muscles holds the more protein the muscle stores. Testosterone can also increase the levels of another anabolic hormone, IGF-1, in muscle tissue (3). Testosterone also has the amazing ability to increase the activity of satellite cells (4). These cells play a very active role in repairing damaged muscle. Testosterone also binds to the androgen receptor to promote A.R dependant mechanisms for muscle gain and fat loss, (5) it also significantly increases the concentrations of the A. R in cells critical for muscle repair and growth and A.R in muscle.(4, 6 ). Testosterone induces changes in shape, size and also can change the appearance and the number of muscle fibers (7). Androgens like testosterone can protect your hard earned muscle from the catabolic (muscle wasting) glucocorticoid hormones (8), thus inhibiting the actions of them. In addition, Testosterone has the ability to increase red blood cell production (9), and a higher RBC count may improve endurance via better oxygenated blood. More RBCs can also improve recovery from strenuous physical activity. As you may have suspected, Testosterones´ anabolic/androgenic effects are dose dependant, the higher the dose the higher the muscle building effect (10).

Steroid.com members report massive strength gains while using testosterone (11). Testosterone improves muscle contraction by increasing the number of motor neutrons in muscle (4) and improves neuromuscular transmission (12). It also promotes glycogen synthesis (13) providing more fuel for intense workouts thus increasing endurance and strength. Also note that the water retention from testosterone use will cause the muscle to spring back when compressed during the lowering of a weight. Testosterone promotes aggressive and dominant behavior (14), this would explain the boost of confidence which gives athletes the mental edge they need to move the heavy iron.

Testosterone is also good at promoting fat loss. Having an anti-estrogenic effect it creates an ideal fat loss environment. Test binds to the A.R on fat cells resulting in fat break-down and also prevents new fat formation.(15) Another indirect action of fat loss that test produces is the nutrient portioning effect it has on muscle and fat. Since the body is building muscle at an accelerated rate more of the food you eat is shuttled to muscle tissue and away from fat.

Is there anything testosterone can´t do?

17b-hydroxy-4-androsten-3-one
    Testosterone base + cypionate ester
    Formula: C27 H40 O3
    Molecular Weight: 412.6112
    Molecular Weight (base): 288.429
    Molecular Weight (ester): 132.1184
    Formula (base): C19 H28 O2
    Formula (ester): C8 H14 O2
    Melting Point (base): 155
    Melting Point (ester): 98 - 104 C
    Manufacturer: Various
    Effective Dose (Men): 300-2000mg+ week
    Effective Dose (Women): Not recommended
    Active life: 15-16 days
    Detection Time: 3 months
    Anabolic/Androgenic ratio:100/100.

References:

  1. Heart. 2004 Aug;90(8):871-6.
  2. J Clin Endocrinol Metab. 1997 Feb;82(2):407-13.
  3. Am J Physiol Endocrinol Metab. 2002 Mar;282(3):E601-7.
  4. Curr Opin Clin Nutr Metab Care. 2004 May;7(3):271-7.
  5. Curr Pharm Biotechnol. 2004 Oct;5(5):459-70.
  6. J Clin Endocrinol Metab. 2004 Oct;89(10):5245-55.
  7. Anat Histol Embryol. 2003 Apr;32(2):70-9.
  8. J Lab Clin Med. 1995 Mar;125(3):326-33.
  9. Zhonghua Nan Ke Xue. 2003;9(4):248-51
  10. J Clin Endocrinol Metab. 2003 Apr;88(4):1478-85
  11. steriod.com/forums
  12. J Appl Physiol. 2001 Mar;90(3):850-6.
  13. Can J Physiol Pharmacol. 1999 Apr;77(4):300-4.
  14. Health Psychol. 1990;9(6):774-91.
  15. Biochim Biophys Acta. 1995 May 11;1244(1):117-20.
  16. Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E222-E227. Epub 2004 Sep 14.
  17. J Clin Endocrinol Metab. 2004 Dec 21
  18. Sports Med. 2004;34(12):809-24.
  19. Heart. 2004 Aug;90(8):871-6.
  20. Pol J Pharmacol. 2004 Sep-Oct;56(5):509-18.
  21. Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1140-5. Epub 2002 Jan 22.
  22. J Gerontol A Biol Sci Med Sci. 2001 May;56(5):M266-72.
  23. J Clin Endocrinol Metab. 2005 Feb;90(2):678-88. Epub 2004 Nov 23.
  24. Fertility and Sterility 33. (1980) 201-3
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